A1492 and A1493 Notes: Definitions & Explanations PDF | Download eBooks
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A1492 and A1493 Definition:
Two universally conserved bases in 16S rRNA that play a critical role in codon-anticodon recognition by inserting into the minor groove between codon and anticodon and stabilizing the interaction..
Molecular Biology by Robert F. Weaver
A1492 and A1493 Notes:
A1492 and A1493 are two universally conserved bases in 16S rRNA that are critical for codon - anticodon recognition. These insert into the minor groove, between the codon and anticodon and stabilize the interaction. In the 30S A site of rRNA, A1493C or any substitution of G530 or A1492 leads to the complete loss of translation activity. Whereas, A1493U and A1493G decrease translation activity by >20-fold.
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