Acidic Domain Notes: Definitions & Explanations PDF | Download eBooks
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Acidic Domain Definition:
A transcription-activating domain rich in acidic amino acids..
Molecular Biology by Robert F. Weaver
Acidic Domain Notes:
Acidic domain, as the name implies, is an amino acid rich, transcription activating domain in cells. For example, in EBV (Epstein-Barr virus) infected cells, the domain that is required for activation of transcription is present at the C terminus and is constituted by two very different amino acid regions, and the one that is more acidic (the second putative α-helix) is an activating domain. While the other proline rich region is not self sufficient for such activation.
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