Partition Coefficient Notes: Definitions & Explanations PDF Download

Study Partition Coefficient lecture notes PDF with college chemistry definitions and explanation to study What is Partition Coefficient?. Study partition coefficient explanation with college chemistry terms to review chemistry course for online degree programs.

Partition Coefficient Notes:

In the physical sciences, a partition coefficient (P) is the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium. This ratio is therefore a measure of the difference in solubility of the compound in these two phases. The partition coefficient may be further expressed as the concentration ratio of un-ionized species of compound, In the chemical and pharmaceutical sciences, both phases generally are solvents. Oftenly, one of the solvents is water, and the second is hydrophobic, such as 1-octanol. Hence the partition coefficient measures how hydrophilic ("water-loving") or hydrophobic ("water-fearing") a chemical substance is. Uses of Partition coefficients are in estimating the distribution of drugs within the body. If one of the solvents is a gas and the other a liquid, a gas/liquid partition coefficient is possible to be determined.Partition coefficients can be measured experimentally in various ways.

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