Lock And Key Mechanism Notes: Definitions & Explanations PDF Download

Study Lock And Key Mechanism lecture notes PDF with college chemistry definitions and explanation to study What is Lock-And-Key Mechanism?. Study lock and key mechanism explanation with college chemistry terms to review chemistry course for online degree programs.

Lock And Key Mechanism Notes:

Lock and key mechanism is a mechanism introduced in 1890 by Emil Fischer to explain binding between the active site of an enzyme and a substrate molecule. The active site was considered to have a fixed structure (the lock), which exactly matched the structure of a specific substrate (the key). Consequently, the enzyme and substrate interact to form an enzyme-substrate complex. The substrate is transformed to products that is not suitable to the active site and are therefore released, liberating the enzyme. Observations made consequent of X-ray diffraction have shown that the active site of an enzyme is more flexible than the lock-and-key theory would have suggested.

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