p53 gene Notes: Definitions & Explanations PDF | Download eBooks
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p53 gene Definition:
P53 gene, named for the 53,000-dalton molecular weight of its protein product, is a tumor-suppressor gene.
Campbell Biology by J.B. Reece, L.A. Urry, M.L. Cain, S.A. Wasserman, P.V. Minorsky, R.B. Jackson
p53 gene Notes:
p53 is an example of a tumor suppressor gene that encode a specific transcription factor that promotes the synthesis of cell cycle-inhibiting proteins, so in this way it functions as a tumor suppressor protein. That is why a mutation that knocks out the p53 gene, like a mutation that leads to a hyperactive Ras protein, can lead to excessive cell growth and cancer because the inhibition of the cell cycle gets abrogated.
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