p53 gene Notes: Definitions & Explanations PDF | Download eBooks
Study p53 gene lecture notes PDF with biology definitions and explanation to study What is p53 gene?. Study p53 gene explanation with biology terms to review biology course for online degree programs.
p53 gene Definition:
P53 gene, named for the 53,000-dalton molecular weight of its protein product, is a tumor-suppressor gene.
Campbell Biology by J.B. Reece, L.A. Urry, M.L. Cain, S.A. Wasserman, P.V. Minorsky, R.B. Jackson
p53 gene Notes:
p53 is an example of a tumor suppressor gene that encode a specific transcription factor that promotes the synthesis of cell cycle-inhibiting proteins, so in this way it functions as a tumor suppressor protein. That is why a mutation that knocks out the p53 gene, like a mutation that leads to a hyperactive Ras protein, can lead to excessive cell growth and cancer because the inhibition of the cell cycle gets abrogated.
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