Philadelphia chromosome Notes: Definitions & Explanations PDF | Download eBooks
Study Philadelphia chromosome lecture notes PDF with biology definitions and explanation to study What is Philadelphia chromosome?. Study philadelphia chromosome explanation with biology terms to review biology course for online degree programs.
Philadelphia chromosome Definition:
Exchange of a large portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shortened, easily recognized chromosome 22, called the Philadelphia chromosome.
Campbell Biology by J.B. Reece, L.A. Urry, M.L. Cain, S.A. Wasserman, P.V. Minorsky, R.B. Jackson
Philadelphia chromosome Notes:
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation, t(9;22)(q34;q11), of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1. So the breaking and joining of a part of chromosome this way activates a gene that makes the cell divide uncontrollably which leads to cancer.
Keep Learning with Biology Notes
What is Aster?
An aster is a cellular structure shaped like a star, comprising of a centrosome and its associated microtubules during the ...
What are Plasmids?
A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell's chromosomal DNA. Plasmids naturally exist ...
What are Tumor suppressor genes?
A tumor suppressor gene, which is also called an antioncogene, is a gene that protects a cell from becoming cancerous. ...
What is RNA primer?
The DNA replication cannot just begin on its own on the template strand. One of the important things that need ...
What is Theory?
A theory is a plausible or scientifically acceptable general principle or body of principles offered to explain phenomena, for example ...
What is Metabolism?
Metabolism is the set of life-sustaining chemical reactions in organisms. The three main purposes of metabolism are: the conversion of ...
