Philadelphia chromosome Notes: Definitions & Explanations PDF | Download eBooks
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Philadelphia chromosome Definition:
Exchange of a large portion of chromosome 22 with a small fragment from a tip of chromosome 9 produces a much shortened, easily recognized chromosome 22, called the Philadelphia chromosome.
Campbell Biology by J.B. Reece, L.A. Urry, M.L. Cain, S.A. Wasserman, P.V. Minorsky, R.B. Jackson
Philadelphia chromosome Notes:
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation, t(9;22)(q34;q11), of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1. So the breaking and joining of a part of chromosome this way activates a gene that makes the cell divide uncontrollably which leads to cancer.
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